John Newport Langley

Overview of John Newport Langley's contributions to physiology

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John Newport Langley

John Newport Langley (1852–1925) was a prominent British physiologist known for his pioneering work in the field of neuroscience and physiology. He made significant contributions to the understanding of the autonomic nervous system and introduced the concept of "receptive substances," which laid the groundwork for the modern understanding of receptors in pharmacology.

Early Life and Education

John Newport Langley was born on June 2, 1852, in Newbury, Berkshire, England. He was educated at Rugby School and later attended St John's College, Cambridge, where he studied natural sciences. Langley graduated with a Bachelor of Arts degree in 1875 and subsequently became a fellow of St John's College.

Academic Career

Langley began his academic career at the University of Cambridge, where he worked closely with Michael Foster, a leading physiologist of the time. In 1884, Langley was appointed as the first Professor of Physiology at Cambridge, a position he held until his death in 1925.

Contributions to Physiology

Langley's research focused on the nervous system, particularly the autonomic nervous system. He was instrumental in distinguishing between the sympathetic nervous system and the parasympathetic nervous system.

Autonomic Nervous System

Langley coined the term "autonomic nervous system" to describe the part of the nervous system that controls involuntary bodily functions. His work helped to clarify the roles of the sympathetic and parasympathetic divisions, which are responsible for the body's "fight or flight" and "rest and digest" responses, respectively.

Receptive Substances

Langley introduced the concept of "receptive substances" in 1905, which referred to the specific sites on cells that interact with neurotransmitters and hormones. This concept was a precursor to the modern understanding of receptors and their role in cell signaling.

Legacy

Langley's work laid the foundation for future research in neuropharmacology and neurobiology. His introduction of the concept of receptors has had a lasting impact on the development of pharmacology and the study of drug action.

Personal Life

Langley was known for his dedication to teaching and research. He was married to Mary Louisa, and they had two children. Langley passed away on November 5, 1925, in Cambridge, England.

Related pages

• Autonomic nervous system
• Receptor (biochemistry)
• Sympathetic nervous system
• Parasympathetic nervous system