Juvenile myelomonocytic leukemia

Juvenile myelomonocytic leukemia (JMML) is a rare and serious form of blood cancer that affects children. It is characterized by the overproduction of white blood cells in the bone marrow, leading to severe health complications.

Symptoms

The symptoms of JMML can vary, but often include fever, fatigue, weight loss, rash, and enlarged spleen or liver.

Causes

The exact cause of JMML is unknown, but it is believed to be related to genetic mutations. Some children with JMML have a history of neurofibromatosis type 1 or Noonan syndrome, which are genetic disorders that increase the risk of developing certain types of cancer.

Diagnosis

Diagnosis of JMML is based on a combination of clinical symptoms, blood tests, and bone marrow examination. Genetic testing may also be performed to identify any underlying genetic disorders.

Treatment

Treatment for JMML typically involves chemotherapy to destroy the cancerous cells, followed by a stem cell transplant to replace the damaged bone marrow. This can be a challenging and intensive process, but it is currently the most effective treatment for JMML.

Prognosis

The prognosis for children with JMML varies widely. Some children respond well to treatment and can achieve long-term remission, while others may not respond to treatment or may experience a relapse.

See also

• Leukemia
• Pediatric oncology
• Bone marrow transplant

References

Juvenile myelomonocytic leukemia Resources
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