Juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is a rare and serious form of blood cancer that affects children. It is characterized by the overproduction of white blood cells in the bone marrow, leading to severe health complications.
Symptoms[edit | edit source]
The symptoms of JMML can vary, but often include fever, fatigue, weight loss, rash, and enlarged spleen or liver.
Causes[edit | edit source]
The exact cause of JMML is unknown, but it is believed to be related to genetic mutations. Some children with JMML have a history of neurofibromatosis type 1 or Noonan syndrome, which are genetic disorders that increase the risk of developing certain types of cancer.
Diagnosis[edit | edit source]
Diagnosis of JMML is based on a combination of clinical symptoms, blood tests, and bone marrow examination. Genetic testing may also be performed to identify any underlying genetic disorders.
Treatment[edit | edit source]
Treatment for JMML typically involves chemotherapy to destroy the cancerous cells, followed by a stem cell transplant to replace the damaged bone marrow. This can be a challenging and intensive process, but it is currently the most effective treatment for JMML.
Prognosis[edit | edit source]
The prognosis for children with JMML varies widely. Some children respond well to treatment and can achieve long-term remission, while others may not respond to treatment or may experience a relapse.
See also[edit | edit source]
References[edit | edit source]
| Juvenile myelomonocytic leukemia Resources | |
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Contributors: Prab R. Tumpati, MD
