KCNIP2

KCNIP2 is a gene that encodes a member of the Kv channel-interacting protein (KCNIP) family. KCNIP family members are small calcium binding proteins. They all have N-terminal EF-hand domains, and are differentially expressed in many tissues. They bind to another family of proteins, voltage-gated potassium (Kv) channels, and modulate Kv function, including the voltage-gated ion channel activity. KCNIP2 is also known as KCHIP2 or potassium voltage-gated channel interacting protein 2.

Function

KCNIP2 is involved in the regulation of cardiac electrophysiology and neuronal excitability. It functions by interacting with voltage-gated potassium channels, specifically the Kv4/D (Shal) subfamily of channels. This interaction results in an increase in the surface expression of the channels and a slowing of channel inactivation.

Clinical Significance

Mutations in the KCNIP2 gene have been associated with various cardiac diseases, including Brugada syndrome and atrial fibrillation. Studies have also suggested a potential role in neurological disorders such as Alzheimer's disease and epilepsy, although more research is needed in these areas.

Research

Research into the KCNIP2 gene and its associated protein continues to be an active area of study. Understanding the precise mechanisms by which this gene and protein function could lead to new treatments for a variety of cardiac and neurological disorders.

See Also

• Kv channel-interacting protein
• Voltage-gated potassium channel
• Cardiac electrophysiology
• Neuronal excitability