KDM2B

KDM2B (also known as Lysine Demethylase 2B) is a protein that in humans is encoded by the KDM2B gene. It is a member of the Jumonji C (JmjC) domain containing family of proteins, which are involved in the regulation of gene expression through the demethylation of histones.

Function

KDM2B is a histone demethylase that specifically demethylates 'Lys-4' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. It preferentially demethylates mono- and dimethylated H3 'Lys-4' and 'Lys-36' residue, while it has weak or no activity on trimethylated forms. It also demethylates monomethylated H3 'Lys-9' and H3 'Lys-27' residue, but with much less efficiency than 'Lys-4' and 'Lys-36' residue. Demethylation of Lys residue generates formaldehyde and succinate.

Clinical significance

Alterations in the function of KDM2B have been implicated in several diseases, including cancer. Overexpression of KDM2B has been observed in various types of cancer, including breast cancer, lung cancer, and leukemia. It is thought that the overexpression of KDM2B may contribute to the development of cancer by promoting the proliferation of cancer cells and inhibiting their apoptosis.

See also

• Histone demethylase
• Jumonji C (JmjC) domain
• Gene expression
• Histone

External links

• NCBI Gene
• UniProt

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