KDM5A

KDM5A (also known as Lysine Demethylase 5A) is a protein that in humans is encoded by the KDM5A gene. This protein is a member of the Jumonji C (JmjC) domain containing family of proteins, which are involved in the regulation of gene expression through the demethylation of histones.

Function

KDM5A is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. It preferentially demethylates tri- and di-methylated lysine 4 (H3K4me3 and H3K4me2). KDM5A is directly involved in cell cycle progression and is necessary for cell proliferation and DNA repair.

Clinical Significance

Alterations in the KDM5A gene have been associated with various types of cancer, including lung cancer, breast cancer, and leukemia. In addition, KDM5A has been implicated in neurodevelopmental disorders, such as autism and intellectual disability.

Research

Research into KDM5A is ongoing, with studies focusing on its role in cancer development and progression, as well as its potential as a therapeutic target for cancer treatment.

See Also

• Histone Demethylase
• Epigenetics
• Gene Expression
• Cancer