KLF2

KLF2 (Kruppel-like factor 2) is a transcription factor that plays a crucial role in the regulation of gene expression in endothelial cells. It is part of the Kruppel-like factor family, which is involved in various cellular processes including cell proliferation, differentiation, and apoptosis.

Function

KLF2 is primarily expressed in the vascular endothelium and is known to regulate the expression of genes involved in vascular tone, inflammation, and thrombosis. It acts as a key regulator of endothelial homeostasis and is essential for maintaining vascular integrity.

KLF2 modulates the expression of eNOS (endothelial nitric oxide synthase), which is critical for the production of nitric oxide, a molecule that plays a significant role in vasodilation and blood pressure regulation.

Clinical Significance

Alterations in KLF2 expression have been associated with various cardiovascular diseases, including atherosclerosis, hypertension, and thrombosis. Studies have shown that KLF2 expression is reduced in atherosclerotic lesions, suggesting its protective role against vascular inflammation and plaque formation.

KLF2 is also being studied for its potential role in cancer, as it may influence tumor angiogenesis and metastasis.

Research

Recent research has focused on the role of KLF2 in immune regulation and its potential as a therapeutic target in autoimmune diseases. KLF2 has been shown to influence the trafficking of lymphocytes and the expression of adhesion molecules, which are critical for immune cell migration.

See Also

• Transcription factor
• Endothelial cell
• Vascular biology
• Gene expression

External Links

• [KLF2 at GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=KLF2)
• [KLF2 at NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/10365)