KLF2

KLF2 (Kruppel Like Factor 2) is a protein that in humans is encoded by the KLF2 gene. It is a member of the Kruppel-like factor family of zinc finger proteins. KLF2 plays a crucial role in lymphocyte trafficking, blood vessel development, and lung maturation.

Function

KLF2 is a transcription factor that binds to the promoter regions of its target genes and regulates their expression. It is involved in the regulation of T cell quiescence and endothelial cell activation. In endothelial cells, KLF2 regulates the expression of thrombomodulin, a protein that plays a key role in the anticoagulant pathway.

Clinical Significance

Alterations in the expression of KLF2 have been associated with several diseases. For example, reduced expression of KLF2 has been observed in patients with atherosclerosis, and it has been suggested that KLF2 may have a protective role in this disease. In addition, mutations in the KLF2 gene have been identified in patients with congenital heart disease.

Research

Research on KLF2 is ongoing, with studies focusing on its role in immune response, cardiovascular disease, and cancer. Understanding the function of KLF2 and its role in disease may lead to the development of new therapeutic strategies.

File:KLF2 protein structure.jpg

Structure of the KLF2 protein. Image from Wikimedia Commons.

See Also

• Kruppel-like factors
• Transcription factor
• Zinc finger protein