KRas
| Kallikrein-related peptidase 9 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ? | ||||||
| HGNC | 6357 | ||||||
| OMIM | 605840 | ||||||
| RefSeq | NM_145894 | ||||||
| UniProt | Q9UKR3 | ||||||
| Other data | |||||||
| EC number | 3.4.21.- | ||||||
| |||||||
Kallikrein-related peptidase 9 (KLK9) is a member of the kallikrein subfamily of serine proteases, which are enzymes that cleave peptide bonds in proteins. KLK9 is encoded by the KLK9 gene located on chromosome 19q13.3, a region known for containing a cluster of kallikrein genes.
Structure[edit | edit source]
The KLK9 gene is composed of five exons and encodes a preproprotein that is processed to generate the mature enzyme. The mature KLK9 protein consists of approximately 250 amino acids and contains the characteristic serine protease catalytic triad: histidine, aspartate, and serine.
Function[edit | edit source]
KLK9 is involved in various physiological processes, including skin desquamation, semen liquefaction, and possibly in the regulation of blood pressure. Like other kallikreins, KLK9 is thought to play a role in the degradation of extracellular matrix components, which is important in tissue remodeling and repair.
Expression[edit | edit source]
KLK9 is expressed in a variety of tissues, with the highest levels found in the central nervous system, ovary, and testis. Its expression is regulated by steroid hormones, particularly androgens and estrogens, suggesting a role in reproductive physiology.
Clinical Significance[edit | edit source]
Altered expression of KLK9 has been observed in several types of cancer, including breast cancer and ovarian cancer. It is being studied as a potential biomarker for cancer diagnosis and prognosis. Elevated levels of KLK9 in serum or tissue samples may correlate with disease progression or response to therapy.
Research[edit | edit source]
Ongoing research is focused on understanding the precise biological functions of KLK9 and its potential as a therapeutic target. Studies are also investigating the role of KLK9 in neurodegenerative diseases and its involvement in inflammatory processes.
Also see[edit | edit source]
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