Kelly Metcalfe

File:Dr. Kelly Metcalfe.jpg

Kelly Metcalfe

Name	Kelly Metcalfe
Birth name
Birth date
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Death date
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Alma mater
Occupation	Professor, Researcher
Years active
Organization
Known for	Breast cancer research, BRCA1 and BRCA2 gene studies
Notable works
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Kelly Metcalfe is a renowned Canadian researcher and professor known for her significant contributions to the field of breast cancer research, particularly in the study of BRCA1 and BRCA2 gene mutations. Her work has been instrumental in advancing the understanding of genetic predispositions to breast cancer and informing clinical practices for risk management and treatment.

Early Life and Education

Kelly Metcalfe was born in Canada, where she pursued her early education. She developed an interest in genetics and oncology, which led her to pursue higher education in these fields. Metcalfe completed her undergraduate studies in nursing, followed by a master's degree and a Ph.D. in a related field, focusing on genetic epidemiology and cancer research.

Career

Metcalfe began her career as a clinical nurse, where she gained firsthand experience in patient care and the challenges faced by individuals with cancer. Her clinical background provided a strong foundation for her transition into research.

She joined the faculty at the University of Toronto, where she is currently a professor in the Lawrence S. Bloomberg Faculty of Nursing. Metcalfe is also affiliated with the Women's College Research Institute, where she conducts her research on hereditary breast cancer.

Research Contributions

Kelly Metcalfe's research primarily focuses on the genetic aspects of breast cancer, particularly the impact of BRCA1 and BRCA2 mutations. These genes, when mutated, significantly increase the risk of developing breast and ovarian cancers.

BRCA1 and BRCA2 Studies

Metcalfe has conducted extensive studies on the prevalence and impact of BRCA1 and BRCA2 mutations in various populations. Her research has helped to identify the risk factors associated with these mutations and has contributed to the development of guidelines for genetic testing and counseling.

Risk Management Strategies

One of Metcalfe's key contributions is her work on risk management strategies for individuals with BRCA mutations. She has explored the effectiveness of preventive measures such as prophylactic mastectomy and oophorectomy, as well as the role of surveillance and lifestyle modifications in reducing cancer risk.

Impact on Clinical Practice

Metcalfe's research has had a significant impact on clinical practice, particularly in the areas of genetic counseling and personalized medicine. Her findings have informed guidelines for the management of hereditary breast cancer and have been incorporated into clinical protocols worldwide.

Awards and Recognition

Kelly Metcalfe has received numerous awards and honors for her contributions to cancer research. She is recognized as a leading expert in her field and is frequently invited to speak at international conferences and symposia.

Also see

• Breast cancer
• Genetic counseling
• BRCA1
• BRCA2
• Hereditary cancer