Kleiner Holmes syndrome

Alternate names[edit | edit source]

Hallux varus and preaxial polysyndactyly

Definition[edit | edit source]

Hallux varus-preaxial polysyndactyly syndrome is a rare, genetic, congenital limb malformation disorder characterized by bilateral medial displacement of the hallux and preaxial polysyndactyly of the first toes. Radiographs show broad, shortened, misshapen first metatarsals and may associate incomplete or complete duplication of proximal phalanges and duplication or triplication of distal phalanges. There have been no further descriptions in the literature since 1980.

NIH genetic and rare disease info[edit source]

NIH info on Kleiner Holmes syndrome

Kleiner Holmes syndrome is a rare disease.

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Resources	NIH GARD, US Genetic and Rare Diseases Info Rare Disease Day Undiagnosed Diseases Network Database of rare diseases at Orphanet Rare Disease UK Rare diseases search engine