L-733,060

L-733,060 is a drug that acts as a potent and selective antagonist for the neurokinin 1 receptor. It was developed by Merck & Co and has been researched for potential use in the treatment of depression and anxiety, but was not pursued for clinical use.

Pharmacology

L-733,060 is a neurokinin 1 receptor antagonist, meaning it blocks the action of the neurokinin 1 (NK1) receptor. The NK1 receptor is a G protein-coupled receptor located in the central and peripheral nervous system, which is activated by the neuropeptide substance P. It is involved in various biological functions, including pain perception, mood regulation, and immune response modulation.

Clinical significance

Research has suggested that NK1 receptor antagonists like L-733,060 could have potential therapeutic uses. For example, they may be useful in the treatment of depression and anxiety. However, despite these potential applications, L-733,060 has not been pursued for clinical use.

See also

• Neurokinin 1 receptor
• Substance P
• Depression (mood)
• Anxiety

References

L-733,060 Resources
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