LHRH
Luteinizing Hormone-Releasing Hormone (LHRH)
Luteinizing Hormone-Releasing Hormone (LHRH), also known as Gonadotropin-releasing hormone (GnRH), is a peptide hormone responsible for the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary. LHRH is a key player in the hypothalamic–pituitary–gonadal axis (HPG axis).
Function[edit | edit source]
LHRH is secreted in the hypothalamus and travels to the anterior pituitary via the hypophyseal portal system. It acts on gonadotrophs in the anterior pituitary, causing the release of LH and FSH. These hormones then act on the gonads, stimulating the production of sex steroids and the process of gametogenesis.
Clinical significance[edit | edit source]
LHRH and its analogs are used in the treatment of several medical conditions, including prostate cancer, breast cancer, endometriosis, uterine fibroids, and precocious puberty. LHRH analogs can be used to suppress the production of sex steroids, thereby reducing the symptoms of these conditions.
See also[edit | edit source]
- Luteinizing hormone
- Follicle-stimulating hormone
- Gonadotropin-releasing hormone
- Hypothalamic–pituitary–gonadal axis
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
