LPAR1

LPAR1 or Lysophosphatidic Acid Receptor 1 is a protein that in humans is encoded by the LPAR1 gene. It is a member of the G protein-coupled receptor family and plays a crucial role in several biological processes, including cell proliferation, cell differentiation, and apoptosis.

Function[edit | edit source]

LPAR1 is a receptor for lysophosphatidic acid (LPA), a bioactive lipid mediator that influences various biological functions. Upon binding with LPA, LPAR1 activates a series of intracellular signaling pathways, including the phospholipase C pathway, Rho kinase pathway, and adenylate cyclase inhibition. This leads to cellular responses such as cell proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, tumor cell invasion and more.

Clinical Significance[edit | edit source]

Alterations in LPAR1 expression or function have been associated with various pathologies, including cancer, fibrosis, inflammation, and neurological disorders. For instance, overexpression of LPAR1 has been observed in ovarian, thyroid, and colorectal cancers, suggesting a potential role in tumor progression. In addition, LPAR1 antagonists are being explored as potential therapeutic agents for the treatment of idiopathic pulmonary fibrosis and other fibrotic diseases.