LRP1B

LRP1B (Low-Density Lipoprotein Receptor-Related Protein 1B) is a protein that in humans is encoded by the LRP1B gene. It is a member of the LDL receptor family, which plays a critical role in the metabolism of lipoproteins and protection against atherosclerosis.

Function

LRP1B is involved in endocytosis, but its function is not yet fully understood. It is known to bind and internalize ligands in the process of receptor-mediated endocytosis and to play a critical role in the migration of neurons during development.

Clinical significance

Mutations in the LRP1B gene have been associated with obesity and a higher risk of cancer, particularly lung and oral cancers. It is also considered a tumor suppressor gene, as its loss of function can lead to increased cell proliferation and cancer progression.

See also

• Low-density lipoprotein receptor
• Endocytosis
• Tumor suppressor gene

References

LRP1B Resources
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