Lanimostim
Lanimostim is a recombinant form of granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine that plays a crucial role in the proliferation and differentiation of hematopoietic progenitor cells into granulocytes and macrophages. It is used in clinical settings to enhance the immune system, particularly in patients undergoing chemotherapy or bone marrow transplantation.
Mechanism of Action[edit | edit source]
Lanimostim functions by binding to specific receptors on the surface of hematopoietic progenitor cells. This binding activates intracellular signaling pathways that lead to the proliferation and differentiation of these progenitor cells into mature granulocytes and macrophages. These cells are essential components of the innate immune system, providing a first line of defense against infections.
Clinical Applications[edit | edit source]
Lanimostim is primarily used in patients who have undergone chemotherapy or bone marrow transplantation. These treatments often result in neutropenia, a condition characterized by an abnormally low count of neutrophils, which are a type of granulocyte. By stimulating the production of granulocytes and macrophages, Lanimostim helps to reduce the duration and severity of neutropenia, thereby decreasing the risk of infections.
Side Effects[edit | edit source]
Common side effects of Lanimostim include bone pain, fever, and fatigue. These are generally mild and manageable. However, in some cases, patients may experience more severe reactions such as allergic reactions, capillary leak syndrome, or pulmonary edema. It is important for healthcare providers to monitor patients closely for any adverse effects.
Pharmacokinetics[edit | edit source]
Lanimostim is typically administered via subcutaneous or intravenous injection. The pharmacokinetics of Lanimostim involve rapid absorption and distribution throughout the body, with a half-life that allows for once-daily dosing in most therapeutic regimens.
Research and Development[edit | edit source]
Ongoing research is exploring the potential of Lanimostim in other clinical settings, such as in the treatment of autoimmune diseases and as an adjuvant in cancer immunotherapy.
Also see[edit | edit source]
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
