Large neutral amino acids transporter small subunit 3
Large Neutral Amino Acids Transporter Small Subunit 3 (LAT3) is a protein that in humans is encoded by the SLC43A1 gene. It is a member of the solute carrier family, specifically the L-type amino acid transporters (LATs). LAT3 is primarily expressed in the liver and placenta, and to a lesser extent in the kidney and brain.
Function[edit | edit source]
LAT3 is a system L amino acid transporter that facilitates the transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. In contrast to other members of the system L family, it has a low affinity for methionine and histidine. It is an obligatory exchanger and its principal physiological function is to carry out the exchange of extracellular leucine for intracellular arginine.
Clinical significance[edit | edit source]
Alterations in LAT3 function can lead to various health conditions. For instance, overexpression of LAT3 has been associated with prostate cancer and breast cancer, suggesting a role in tumor growth and survival. In addition, mutations in the SLC43A1 gene can lead to a rare inherited disorder called hyperdibasic aminoaciduria type 2, characterized by an excess of certain amino acids in the urine.
See also[edit | edit source]
References[edit | edit source]
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD