Late-onset distal myopathy, Markesbery-Griggs type
Alternate names[edit | edit source]
ZASP-related myofibrillar myopathy
Definition[edit | edit source]
A rare, genetic, non-dystrophic myofibrillar myopathy disorder characterized by late-adult onset of distal and/or proximal limb muscle weakness with initial involvement of posterior lower leg muscles, medial gastrocnemius and soleus. Patients present with ankle weakness followed by weakness of finger and wrist extensors and later on of proximal muscles. Ambulation is usually preserved. Late-onset associated cardiomyopathy and/or neuropathy has been reported in a minority of cases.
NIH genetic and rare disease info[edit source]
Late-onset distal myopathy, Markesbery-Griggs type is a rare disease.
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