Becker's muscular dystrophy

Becker's muscular dystrophy (BMD) is a genetic disorder that progressively weakens the body's muscles. It is named after the German doctor, Peter Emil Becker, who first described this variant of muscular dystrophy. BMD is similar to Duchenne muscular dystrophy, but its onset is usually in the late teens or early adulthood and it progresses more slowly.

Causes

BMD is caused by mutations in the dystrophin gene. This gene is responsible for the production of a protein essential for maintaining the integrity of muscle fibers. Mutations in the dystrophin gene prevent the body from producing enough functional dystrophin, leading to the progressive muscle degeneration and weakness characteristic of BMD.

Symptoms

The symptoms of BMD can vary widely among affected individuals. They typically begin in adolescence or early adulthood and may include muscle weakness, difficulty walking, and fatigue. As the disease progresses, affected individuals may require the use of a wheelchair. Other symptoms can include cardiomyopathy, a condition that weakens and enlarges the heart, and respiratory problems.

Diagnosis

BMD is diagnosed through a combination of clinical examination, family history, and genetic testing. Muscle biopsy may also be performed to confirm the diagnosis.

Treatment

There is currently no cure for BMD. Treatment is focused on managing symptoms and improving quality of life. This may include physical therapy, occupational therapy, and the use of assistive devices. Medications may also be used to manage symptoms such as heart problems.

Prognosis

The prognosis for individuals with BMD varies. Some individuals maintain a good quality of life with minimal disability, while others may experience significant disability and health problems. The disease progresses more slowly than Duchenne muscular dystrophy, and most individuals with BMD live into adulthood.

See also

• Duchenne muscular dystrophy
• Genetic disorder
• Muscular dystrophy