Leslie Z. Benet

Benet May 23 2023

Leslie Z. Benet is a prominent American pharmacologist and pharmaceutical scientist. He is widely recognized for his contributions to the fields of pharmacokinetics and pharmacodynamics. Benet has made significant advancements in understanding drug absorption, distribution, metabolism, and excretion (ADME).

Early Life and Education

Leslie Z. Benet was born in New York City. He completed his undergraduate studies at University of California, Berkeley, where he earned a Bachelor of Science degree in pharmacy. He then pursued a Ph.D. in pharmaceutical chemistry at the University of California, San Francisco (UCSF).

Career

Benet began his academic career at UCSF, where he has held various positions, including Professor of Bioengineering and Therapeutic Sciences. He has also served as the Chairman of the Department of Pharmacy.

Research Contributions

Benet's research has focused on the mechanisms of drug transport and metabolism. He is particularly known for his work on the Biopharmaceutics Classification System (BCS), which categorizes drugs based on their solubility and permeability. This system has been widely adopted by regulatory agencies, including the Food and Drug Administration (FDA), to streamline the drug approval process.

Biopharmaceutics Classification System (BCS)

The BCS is a scientific framework for classifying drugs based on their aqueous solubility and intestinal permeability. It helps in predicting the drug absorption potential and guides the development of new pharmaceuticals. Benet's contributions to the BCS have been instrumental in improving the efficiency of drug development and regulatory review.

Pharmacokinetics and Pharmacodynamics

Benet has also made significant contributions to the understanding of pharmacokinetics and pharmacodynamics. His research has provided insights into the factors that influence drug bioavailability and therapeutic efficacy. He has published numerous articles and book chapters on these topics, making him a leading authority in the field.

Awards and Honors

Throughout his career, Benet has received numerous awards and honors, including the Oscar B. Hunter Memorial Award in Therapeutics from the American Society for Clinical Pharmacology and Therapeutics (ASCPT) and the Distinguished Pharmaceutical Scientist Award from the American Association of Pharmaceutical Scientists (AAPS).

Professional Memberships

Benet is a member of several professional organizations, including the American Association of Pharmaceutical Scientists (AAPS), the American Society for Clinical Pharmacology and Therapeutics (ASCPT), and the International Pharmaceutical Federation (FIP).

Personal Life

Leslie Z. Benet resides in San Francisco, California. He is married and has two children.

See Also

• Pharmacokinetics
• Pharmacodynamics
• Biopharmaceutics Classification System
• Drug metabolism
• Pharmaceutical sciences

External Links

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