Alkaline phosphatase
(Redirected from Leukocyte alkaline phosphatase)
| Alkaline phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.3.1 | ||||||||
| CAS number | 9001-78-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Alkaline phosphatase (ALP) is an enzyme that is found in many tissues throughout the body, including the liver, bone, kidney, and placenta. It is involved in the process of dephosphorylation, which is the removal of a phosphate group from a molecule.
Function[edit | edit source]
Alkaline phosphatase plays a crucial role in metabolism and signal transduction by dephosphorylating molecules such as nucleotides, proteins, and alkaloids. This enzyme is most active in an alkaline environment, hence its name.
Isoenzymes[edit | edit source]
There are several isoenzymes of alkaline phosphatase, which are classified based on their tissue of origin:
- Liver alkaline phosphatase
- Bone alkaline phosphatase
- Intestinal alkaline phosphatase
- Placental alkaline phosphatase
Clinical significance[edit | edit source]
Elevated levels of alkaline phosphatase in the blood can indicate various medical conditions, including liver disease, bone disorders, and biliary obstruction. Conversely, low levels of ALP can be associated with conditions such as hypophosphatasia.
Diagnostic use[edit | edit source]
Alkaline phosphatase levels are commonly measured in blood tests to help diagnose and monitor diseases. The test is often part of a liver function test panel.
Related enzymes[edit | edit source]
Alkaline phosphatase is part of a larger family of phosphatases, which includes:
See also[edit | edit source]
References[edit | edit source]
 | This enzyme-related article is a stub. You can help WikiMD by expanding it. |
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Contributors: Prab R. Tumpati, MD
