Lipoplatin

Lipoplatin is a liposomal nanoparticle formulation of cisplatin, a chemotherapy drug used in the treatment of various types of cancer. It was developed to reduce the systemic toxicity of cisplatin, while maintaining its antitumor activity.

Composition

Lipoplatin consists of cisplatin encapsulated in liposomes, which are small spherical vesicles composed of phospholipid bilayers. The liposomes protect the cisplatin from degradation and allow it to be delivered directly to tumor cells, reducing its toxicity to healthy tissues.

Mechanism of Action

Like cisplatin, Lipoplatin works by interfering with the DNA in cancer cells, preventing them from dividing and growing. However, because it is encapsulated in liposomes, it is able to target tumor cells more specifically and with less damage to healthy cells.

Clinical Trials

Lipoplatin has been tested in several clinical trials for various types of cancer, including lung cancer, pancreatic cancer, and gastric cancer. The results have shown that it is as effective as cisplatin, but with fewer side effects.

Side Effects

The most common side effects of Lipoplatin are nausea, vomiting, and fatigue. However, these are generally less severe than with cisplatin. Other potential side effects include kidney damage, hearing loss, and neurotoxicity.

See Also

• Chemotherapy
• Cisplatin
• Liposome
• Nanoparticle
• Cancer treatment

References

Lipoplatin Resources
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