Lonidamine

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Lonidamine is a dicarboxylic acid derivative with potential antineoplastic activity. It was first synthesized in the 1970s by the Italian pharmaceutical company Sigma-Tau. Lonidamine is known to inhibit aerobic glycolysis, a process that is often increased in cancer cells.

Mechanism of Action[edit | edit source]

Lonidamine inhibits the mitochondrial hexokinase, an enzyme that plays a key role in the glycolysis pathway. By inhibiting this enzyme, lonidamine disrupts the energy production in cancer cells, leading to cell death. It also inhibits the mitochondrial permeability transition pore, which further disrupts the energy production in cancer cells.

Clinical Use[edit | edit source]

Lonidamine has been studied in clinical trials for the treatment of various types of cancer, including breast cancer, ovarian cancer, and lung cancer. It is often used in combination with other chemotherapy drugs to enhance their effectiveness.

Side Effects[edit | edit source]

The most common side effects of lonidamine include nausea, vomiting, and fatigue. Less common side effects can include neurotoxicity, hepatotoxicity, and testicular atrophy.

Research[edit | edit source]

Research is ongoing to further understand the potential benefits and risks of lonidamine. Some studies are investigating its potential use in radiosensitization, where it could make cancer cells more susceptible to radiation therapy.

See Also[edit | edit source]

Template:Chem-drug-stub

Resources[edit source]

Latest articles - Lonidamine

PubMed
Clinical trials
UpToDate

AI tools[edit source]

Generative AI tools and links to learn more on Lonidamine: ChatGPT - Bing Chat - Google Gemini. (caution advised).


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