Lubazodone
Lubazodone is a serotonin antagonist and reuptake inhibitor (SARI) that was under development by Eli Lilly for the treatment of depression but was never marketed. It acts as a 5-HT2A, 5-HT2C, and 5-HT3 antagonist and serotonin reuptake inhibitor, and also has weak affinity for the alpha-1 and alpha-2 adrenergic and H1 histamine receptors.
History[edit | edit source]
Lubazodone was under development by Eli Lilly in the 1990s for the treatment of depression. However, the development was discontinued and the drug was never marketed.
Pharmacology[edit | edit source]
Lubazodone acts as a 5-HT2A, 5-HT2C, and 5-HT3 antagonist and serotonin reuptake inhibitor. It also has weak affinity for the alpha-1 and alpha-2 adrenergic and H1 histamine receptors.
See also[edit | edit source]
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