Lupus panniculitis

Lupus panniculitis (also known as Lupus profundus) is a rare form of lupus that primarily affects the deep layer of fat in the skin. It is characterized by inflammation and degeneration of the subcutaneous fat layer, leading to the formation of deep-seated, firm nodules and plaques.

Signs and Symptoms

The most common symptom of lupus panniculitis is the presence of firm, deep-seated nodules or plaques in the skin. These can occur anywhere on the body but are most commonly found on the face, arms, thighs, and buttocks. The nodules may be painful and can lead to cosmetic disfigurement if left untreated. Other symptoms may include fatigue, fever, and joint pain.

Causes

The exact cause of lupus panniculitis is unknown. However, it is believed to be an autoimmune disorder, where the body's immune system mistakenly attacks healthy tissue. It is also associated with other forms of lupus, particularly systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE).

Diagnosis

Diagnosis of lupus panniculitis is often challenging due to its rarity and the nonspecific nature of its symptoms. It is typically confirmed through a combination of clinical examination, blood tests, and skin biopsy. The biopsy will show inflammation and degeneration of the subcutaneous fat layer, which is characteristic of this condition.

Treatment

Treatment for lupus panniculitis primarily involves managing symptoms and preventing further damage to the skin. This may include the use of nonsteroidal anti-inflammatory drugs (NSAIDs), antimalarial drugs, and corticosteroids. In severe cases, immunosuppressive drugs may be used.

See Also

• Lupus erythematosus
• Systemic lupus erythematosus
• Discoid lupus erythematosus

References

Lupus panniculitis Resources
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