MDA5
MDA5 (Melanoma Differentiation-Associated protein 5) is a protein that in humans is encoded by the IFIH1 gene. It is a part of the RIG-I-like receptor (RLR) family, which plays a crucial role in the innate immune system by detecting viral RNA and activating a signaling cascade that leads to the production of interferons.
Function[edit | edit source]
MDA5 is a cytoplasmic protein that recognizes double-stranded RNA (dsRNA), a key molecular pattern associated with viral infections. Upon recognition of dsRNA, MDA5 undergoes a conformational change and interacts with the mitochondrial antiviral-signaling protein (MAVS), leading to the activation of transcription factors IRF3 and NF-κB. These transcription factors then induce the expression of type I interferons and other antiviral proteins.
Clinical significance[edit | edit source]
Mutations in the IFIH1 gene have been associated with several autoimmune diseases, including Aicardi-Goutières syndrome, Singleton-Merten syndrome, and type 1 diabetes. In addition, MDA5 has been implicated in the antiviral response to several RNA viruses, including picornaviruses, noroviruses, and coronaviruses.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- IFIH1 gene at NCBI
- MDA5 protein at UniProt
MDA5 Resources | ||
---|---|---|
|
|
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Contributors: Prab R. Tumpati, MD