MDPH

Methylenedioxypyrovalerone (MDPV) is a psychoactive drug with stimulant properties, which acts as a norepinephrine-dopamine reuptake inhibitor (NDRI). First developed in the 1960s by a team at Boehringer Ingelheim, MDPV gained popularity as a designer drug in the early 2000s. Often found in products sold as "bath salts" or "plant food," MDPV is known for its high potential for abuse and addiction. Its effects are similar to those of other stimulants such as amphetamine and cocaine.

Chemistry

MDPV is a member of the substituted cathinone family, which includes compounds structurally related to cathinone, the active component in the khat plant. Its chemical name is 1-(benzo[d][1,3]dioxol-5-yl)-2-(pyrrolidin-1-yl)pentan-1-one, and it has the molecular formula C16H21NO3. MDPV exists in two enantiomers, with the S-enantiomer being more potent.

Pharmacology

As an NDRI, MDPV blocks the reuptake of dopamine and norepinephrine, leading to an increase in the concentration of these neurotransmitters in the brain. This results in stimulant effects, including increased alertness, energy, euphoria, and sociability. However, it also can cause adverse effects such as anxiety, paranoia, hallucinations, and violent behavior.

Legal Status

Due to its high potential for abuse and lack of medical use, MDPV has been classified as a controlled substance in many countries around the world. In the United States, it is listed as a Schedule I drug under the Controlled Substances Act, indicating it has a high potential for abuse and no accepted medical use.

Health Risks

The use of MDPV can lead to severe psychological and physical health risks. Psychologically, it can cause intense cravings, addiction, anxiety, paranoia, and hallucinations. Physically, it can increase heart rate and blood pressure, leading to cardiovascular problems. There have also been reports of hyperthermia, rhabdomyolysis, and death associated with its use.

See Also

• Designer drug
• Stimulant
• Substituted cathinone
• Bath salts (drug)