MDR
Multidrug Resistance (MDR)[edit | edit source]
Multidrug resistance (MDR) is a phenomenon where microorganisms, such as bacteria, viruses, fungi, and parasites, develop resistance to multiple antimicrobial drugs. This resistance can complicate the treatment of infections and is a significant concern in medicine and public health.
Mechanisms of MDR[edit | edit source]
MDR can occur through various mechanisms, including:
- **Efflux pumps**: These are proteins that actively expel antimicrobial agents out of the cell, reducing their intracellular concentration and effectiveness.
- **Enzymatic degradation**: Some microorganisms produce enzymes that can degrade or modify antimicrobial agents, rendering them ineffective.
- **Target modification**: Changes in the microbial target of the drug can reduce the binding affinity of the drug, leading to resistance.
- **Reduced permeability**: Alterations in the cell membrane can prevent antimicrobial agents from entering the cell.
Clinical Implications[edit | edit source]
MDR poses significant challenges in the treatment of infectious diseases. It can lead to:
- **Increased morbidity and mortality**: Infections caused by MDR organisms are often more difficult to treat and can result in higher rates of complications and death.
- **Longer hospital stays**: Patients with MDR infections may require prolonged hospitalization and more intensive care.
- **Higher healthcare costs**: The need for more expensive and complex treatments can increase the overall cost of healthcare.
Examples of MDR Pathogens[edit | edit source]
Some well-known MDR pathogens include:
- Methicillin-resistant Staphylococcus aureus (MRSA)
- Vancomycin-resistant Enterococci (VRE)
- Multidrug-resistant Tuberculosis (MDR-TB)
- Carbapenem-resistant Enterobacteriaceae (CRE)
Prevention and Control[edit | edit source]
Efforts to prevent and control MDR include:
- **Antimicrobial stewardship**: Rational use of antimicrobial agents to minimize the development of resistance.
- **Infection control practices**: Measures such as hand hygiene, isolation of infected patients, and use of personal protective equipment (PPE) to prevent the spread of MDR organisms.
- **Surveillance**: Monitoring and reporting of MDR cases to track trends and implement appropriate interventions.
- **Research and development**: Investment in the development of new antimicrobial agents and alternative therapies.
See Also[edit | edit source]
- Antimicrobial resistance
- Nosocomial infection
- Antibiotic stewardship
- Infectious disease
- Public health
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Contributors: Prab R. Tumpati, MD