MEKK1
MEKK1 (Mitogen-activated protein kinase kinase kinase 1) is a protein that in humans is encoded by the MAP3K1 gene. It is part of the MAPK/ERK pathway, which is an important cell signaling pathway involved in cell growth, differentiation, and survival.
Function[edit | edit source]
MEKK1 is a member of the MAP kinase kinase kinase (MAP3K) family. The protein is found in the cytoplasm and is a component of the mitogen-activated protein kinase (MAPK) signal transduction pathway. It is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.
Clinical significance[edit | edit source]
Mutations in the MAP3K1 gene have been associated with cancer, specifically breast cancer and ovarian cancer. The protein's role in the MAPK/ERK pathway, which is often dysregulated in cancer, makes it a potential target for cancer therapy.
Interactions[edit | edit source]
MEKK1 has been shown to interact with:
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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