MIR223

MIR223 is a microRNA that in humans is encoded by the MIR223 gene. It is located on the X chromosome and plays a crucial role in the regulation of cell differentiation and inflammation.

Function

MIR223 is a non-coding RNA molecule that functions in the regulation of gene expression. It is involved in the control of hematopoiesis, the process by which blood cells are produced in the body. MIR223 has been shown to regulate the differentiation and function of granulocytes, a type of white blood cell that plays a key role in the immune response.

Clinical significance

Alterations in the expression of MIR223 have been associated with a variety of diseases, including cancer, autoimmune diseases, and cardiovascular diseases. In particular, MIR223 has been implicated in the pathogenesis of acute myeloid leukemia (AML), where it is often downregulated. This downregulation is thought to contribute to the abnormal proliferation and survival of leukemia cells.

Research

Research into MIR223 is ongoing, with studies investigating its potential as a therapeutic target in diseases such as AML. Other areas of research include understanding the mechanisms by which MIR223 regulates gene expression and cell function, and exploring its potential role in other diseases.

MicroRNA (miRNA) and mRNA interactions. MIR223 is a type of miRNA.

See also

• MicroRNA
• Gene expression
• Hematopoiesis
• Acute myeloid leukemia

References

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