MIR34A

MIR34A is a microRNA that in humans is encoded by the MIR34A gene. It is a member of the miR-34 family, which also includes MIR34B and MIR34C. MIR34A is known to play a crucial role in several biological processes, including cell cycle regulation, cell differentiation, apoptosis, and cancer suppression.

Function

MIR34A functions as a tumor suppressor by regulating the expression of multiple genes involved in cell proliferation and apoptosis. It targets the mRNA of these genes, leading to their degradation or translational repression. MIR34A is also involved in the regulation of cell differentiation and development, contributing to the maintenance of cellular homeostasis.

Clinical significance

Alterations in the expression of MIR34A have been associated with various types of cancer, including lung cancer, breast cancer, colorectal cancer, and prostate cancer. Reduced expression of MIR34A is often observed in these cancers, suggesting a potential role in tumorigenesis. In addition, MIR34A has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, as well as in cardiovascular diseases.

Research

Current research is focused on understanding the precise mechanisms by which MIR34A regulates gene expression and contributes to disease development. This knowledge could potentially be used to develop new therapeutic strategies for treating diseases associated with MIR34A dysregulation.

File:MIR34A.png

Structure of MIR34A

See also

• MicroRNA
• Gene expression
• Tumor suppressor
• Cancer

References

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