MYC
MYC is a family of regulator genes and proto-oncogenes that code for transcription factors. The MYC proteins (c-Myc, l-Myc, and n-Myc) are a family of transcription factors in the nucleus of a cell that play important roles in cell cycle progression, apoptosis, and cellular transformation.
Function[edit | edit source]
The MYC gene family consists of three members in humans: c-Myc, l-Myc, and n-Myc. These genes encode for transcription factors that regulate the expression of 15% of all genes through binding on Enhancer Box sequences (E-boxes) and recruiting histone acetyltransferases (HATs). This means that MYC proteins control genes responsible for cell growth and division (proliferation), the process by which a cell matures to carry out specific functions (differentiation), and cell death (apoptosis).
Role in Cancer[edit | edit source]
MYC genes have been implicated in the formation of many types of cancer, including lung cancer, small cell lung cancer, breast cancer, and myeloid leukaemia. When MYC is overexpressed, it can lead to increased proliferation and reduced differentiation, leading to the formation of cancerous cells.
Clinical Significance[edit | edit source]
Due to its role in cell proliferation and growth, MYC is a potential target for cancer therapy. Several strategies are being developed to inhibit MYC function, including small molecules, peptides, and RNA interference.
See Also[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
