Mafoprazine

Mafoprazine is a psychotropic drug that belongs to the class of azapirones. It is used in the treatment of various psychiatric disorders. Mafoprazine is known for its anxiolytic and antidepressant properties.

Pharmacology[edit | edit source]

Mafoprazine acts as a serotonin receptor agonist, specifically at the 5-HT1A and 5-HT2A receptors. This action leads to an increase in serotonin levels in the brain, which can help to alleviate symptoms of anxiety and depression.

Clinical Use[edit | edit source]

Mafoprazine is used in the treatment of a variety of psychiatric disorders, including generalized anxiety disorder (GAD), panic disorder, and major depressive disorder (MDD). It may also be used off-label for other conditions, such as insomnia and post-traumatic stress disorder (PTSD).

Side Effects[edit | edit source]

Like all medications, mafoprazine can cause side effects. Common side effects include dizziness, nausea, headache, and fatigue. Less common but more serious side effects can include serotonin syndrome, a potentially life-threatening condition that can occur with excessive serotonin levels in the brain.

Contraindications[edit | edit source]

Mafoprazine should not be used in individuals with a known hypersensitivity to the drug. It should also be used with caution in individuals with a history of cardiac disease, liver disease, or kidney disease, as these conditions can affect the metabolism and excretion of the drug.