Maprotiline

Maprotiline is a tetracyclic antidepressant that is used in the treatment of depression. It is also sometimes used to treat anxiety and sleep disorders. Maprotiline works by increasing the levels of certain chemicals in the brain that help elevate mood.

Mechanism of Action

Maprotiline acts primarily by inhibiting the reuptake of norepinephrine and to a lesser extent serotonin by the presynaptic neuronal membrane. This increases the concentration of these neurotransmitters in the synaptic cleft leading to prolonged neurotransmitter activity.

Side Effects

Common side effects of Maprotiline include drowsiness, dizziness, and dry mouth. Less common side effects can include tachycardia, hypotension, and arrhythmia. In rare cases, Maprotiline can cause seizures.

Contraindications

Maprotiline is contraindicated in individuals with known hypersensitivity to the drug. It should not be used in patients with a history of seizure disorders, severe renal impairment, or in those who have recently had a myocardial infarction.

Interactions

Maprotiline can interact with a number of other medications, including other antidepressants, antipsychotics, and antihistamines. It can also interact with alcohol, leading to increased drowsiness and potential overdose.

Dosage

The usual adult dose of Maprotiline is 75-150 mg per day, divided into 3 or 4 doses. The dose may be increased to a maximum of 225 mg per day if necessary.

See Also

• Antidepressant
• Tetracyclic antidepressant
• Norepinephrine
• Serotonin

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