Marker chromosome

Marker chromosome is a structurally abnormal chromosome that is an additional, abnormal chromosome in a person's cells. It is so called because it is not identifiable as a derivative of a normal chromosome and is thus "marked" as different. Marker chromosomes can result in genetic disorders depending on the genes contained in the marker.

Causes

Marker chromosomes can be derived from any of the 46 typical human chromosomes but are most commonly derived from chromosomes 15 and 16. They can be formed through various mechanisms, including inversions, translocations, and deletions.

Symptoms

The symptoms associated with marker chromosomes vary widely, depending on the genetic material that is present in the marker chromosome. Some individuals with marker chromosomes may have normal health and development, while others may have health problems or developmental delay.

Diagnosis

Marker chromosomes are usually identified during genetic testing for other conditions. They can be detected through karyotyping, a test that provides a picture of a person's chromosomes.

Treatment

There is no specific treatment for the presence of a marker chromosome. Management of health problems or developmental issues associated with a marker chromosome is usually symptomatic and supportive.

See also

• Chromosome abnormality
• Genetic disorder
• Karyotype

References

Marker chromosome Resources
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