Mast cell-dependent urticaria

Mast cell-dependent urticaria is a type of urticaria, or hives, that is caused by the activation of mast cells in the skin. This condition is characterized by the sudden appearance of red, swollen areas on the skin that can be itchy or painful.

Overview

Mast cells are a type of white blood cell that play a crucial role in the body's immune response. They are found in many tissues throughout the body, but are particularly concentrated in the skin, lungs, and digestive tract. When mast cells are activated, they release a variety of chemicals, including histamine, which causes inflammation and other symptoms of an allergic reaction.

In mast cell-dependent urticaria, the mast cells in the skin are activated, causing them to release histamine and other chemicals. This leads to the characteristic symptoms of urticaria, including redness, swelling, and itching.

Causes

The exact cause of mast cell-dependent urticaria is not fully understood. However, it is known that certain triggers can activate mast cells and lead to an outbreak of hives. These triggers can include certain foods, medications, insect bites, and exposure to heat or cold.

Symptoms

The main symptom of mast cell-dependent urticaria is the sudden appearance of red, swollen areas on the skin. These areas, known as wheals, can vary in size and shape, and can appear anywhere on the body. They are often itchy, but can also be painful.

Other symptoms can include a burning sensation in the affected areas, fatigue, and in severe cases, difficulty breathing.

Treatment

Treatment for mast cell-dependent urticaria typically involves avoiding known triggers and taking medications to control symptoms. These medications can include antihistamines, which block the effects of histamine, and corticosteroids, which reduce inflammation.

In severe cases, a type of medication called a mast cell stabilizer may be used. These medications work by preventing the mast cells from releasing their chemicals, thereby reducing the symptoms of urticaria.

See also

• Mast cell
• Urticaria
• Histamine
• Antihistamine
• Corticosteroids