Mast cell sarcoma
Mast cell sarcoma is a rare and aggressive form of mast cell disease. It is characterized by the presence of malignant mast cells in the skin, bone marrow, and other tissues.
Etiology[edit | edit source]
The exact cause of mast cell sarcoma is unknown. However, it is believed to be related to mutations in the KIT gene, which is responsible for the growth and development of mast cells.
Symptoms[edit | edit source]
Symptoms of mast cell sarcoma can vary widely, but often include skin lesions, anemia, fatigue, and weight loss. In some cases, the disease can also cause organomegaly, or enlargement of the organs.
Diagnosis[edit | edit source]
Diagnosis of mast cell sarcoma is typically made through a combination of physical examination, medical history, and laboratory tests. These tests may include a complete blood count, bone marrow biopsy, and immunohistochemistry to identify the presence of malignant mast cells.
Treatment[edit | edit source]
Treatment for mast cell sarcoma typically involves chemotherapy, radiation therapy, and in some cases, stem cell transplantation. The choice of treatment depends on the patient's overall health, the extent of the disease, and the patient's personal preferences.
Prognosis[edit | edit source]
The prognosis for mast cell sarcoma is generally poor, with a median survival time of less than a year. However, some patients may respond well to treatment and achieve long-term remission.
See also[edit | edit source]
NIH genetic and rare disease info[edit source]
Mast cell sarcoma is a rare disease.
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Contributors: Prab R. Tumpati, MD
