Mecigestone
Mecigestone is a synthetic, steroidal progestin that was never marketed. It is a progestogen and hence is a agonist of the progesterone receptor, the biological target of progestogens like progesterone. Mecigestone has strong progestogenic activity and weak glucocorticoid and antimineralocorticoid activity.
Chemistry[edit | edit source]
Mecigestone, also known as 6-methyl-16-methylene-17α-acetoxyprogesterone or as 6-methyl-16-methylene-17α-acetoxypregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone. It is specifically a derivative of 17α-hydroxyprogesterone and is a member of the gestodene and nomegestrol acetate subgroup of 17α-hydroxyprogesterone derivatives, which also includes delmadinone acetate, promegestone, and trimegestone.
Pharmacology[edit | edit source]
As a progestin, mecigestone has progestogenic activity. It also has weak glucocorticoid and antimineralocorticoid activity. The drug has no androgenic, estrogenic, or antiestrogenic activity.
History[edit | edit source]
Mecigestone was first described in the literature in 1971. It was developed by the French pharmaceutical company Roussel Uclaf, but was never marketed.
See also[edit | edit source]
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