Melanin-concentrating hormone receptor 2

Melanin-concentrating hormone receptor 2 (MCHR2) is a protein that in humans is encoded by the MCHR2 gene. It is a member of the G protein-coupled receptor family, and plays a significant role in the regulation of food intake and energy balance.

Function

MCHR2 is a receptor for melanin-concentrating hormone (MCH), a peptide hormone that plays a role in appetite regulation, energy balance, and the regulation of body weight. MCH acts by binding to MCHR2, which triggers a series of intracellular events leading to the physiological response.

Clinical significance

Alterations in the function of MCHR2 have been implicated in a variety of disorders, including obesity, diabetes, and mood disorders. In particular, overactivity of the MCH-MCHR2 system has been linked to obesity and related metabolic disorders.

Pharmacology

Several drugs that target MCHR2 have been developed for the treatment of obesity and other metabolic disorders. These drugs work by blocking the action of MCH, thereby reducing food intake and promoting weight loss.

See also

• Melanin-concentrating hormone receptor 1
• G protein-coupled receptor
• Melanin-concentrating hormone