Mephenytoin

Mephenytoin is a hydantoin derivative and less toxic succedaneum of phenytoin, which is used in the treatment of epilepsy. It is classified as an anticonvulsant, and is only available (generically) in the USA. It is no longer available in the UK.

Pharmacology

Mephenytoin possesses similar anticonvulsant properties to phenytoin. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure activity rather than to abolish the primary focus of seizure discharges.

Side effects

The side effects of mephenytoin are similar to those of phenytoin, including hirsutism, coarsening of the facial features, vitamin D deficiency, and gum hypertrophy. However, mephenytoin is less toxic and better tolerated.

Metabolism

Mephenytoin is metabolized to a derivative, nirvanol, by cytochrome P450 in the liver. It is then excreted in the urine.

See also

• Phenytoin
• Hydantoin

Mephenytoin Resources
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