Mesoridazine besylate

Mesoridazine Besylate is an antipsychotic medication used primarily in the treatment of schizophrenia. It is a member of the phenothiazine class of antipsychotics.

Pharmacology

Mesoridazine Besylate acts by blocking postsynaptic dopamine receptors in the brain, including D1, D2, D3 and D4 receptors. This inhibits dopamine-mediated effects, leading to reduced symptoms of schizophrenia. It also has anticholinergic, alpha-adrenergic blocking, and antihistaminic effects.

Clinical Use

Mesoridazine Besylate is used in the management of schizophrenia and other psychotic disorders. It can help to reduce positive symptoms such as hallucinations, delusions, and thought disorder, as well as negative symptoms like apathy and withdrawal.

Side Effects

Common side effects of Mesoridazine Besylate include drowsiness, dizziness, and blurred vision. It can also cause extrapyramidal symptoms such as tremors, slurred speech, and akathisia. In rare cases, it can lead to serious conditions like neuroleptic malignant syndrome and tardive dyskinesia.

Contraindications

Mesoridazine Besylate is contraindicated in patients with known hypersensitivity to the drug or other phenothiazines. It should also be avoided in patients with severe cardiovascular disease, comatose states, and in patients with a history of QT interval prolongation.

See Also

• Phenothiazine
• Antipsychotic
• Schizophrenia
• Dopamine receptor
• Extrapyramidal symptoms
• Neuroleptic malignant syndrome
• Tardive dyskinesia