Metapristone
Metapristone is a synthetic and steroidal anti-progestogen with additional anti-glucocorticoid and anti-androgen activity. It is used in the treatment of gynecological disorders.
Chemistry[edit | edit source]
Metapristone is a synthetic steroidal anti-progestogen, or an antagonist of the progesterone receptor. It is also an antagonist of the glucocorticoid receptor and has anti-androgen activity.
Pharmacology[edit | edit source]
Metapristone has been found to inhibit the growth of uterine fibroid cells and endometrial cancer cells in vitro and in vivo. It has been proposed for use in the treatment of these conditions.
Clinical use[edit | edit source]
Metapristone is used in the treatment of gynecological disorders such as uterine fibroids and endometrial cancer. It is also being investigated for use in the treatment of breast cancer.
See also[edit | edit source]
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