Methoxyqualone

Methoxyqualone is a sedative and hypnotic medication that belongs to the Quinazolinone class of drugs. It was developed in the 1960s as a safe alternative to barbiturates to treat insomnia and anxiety. However, it was later found to have potential for drug abuse and dependence and was subsequently withdrawn from many markets.

Pharmacology

Methoxyqualone acts as a central nervous system depressant, similar to barbiturates. It enhances the action of the neurotransmitter GABA at the GABA_A receptor, leading to sedative and hypnotic effects. It also has muscle relaxant properties.

Medical uses

Methoxyqualone was primarily used for the treatment of insomnia and anxiety. However, due to its potential for abuse and the development of tolerance, it is no longer widely used.

Side effects

Common side effects of methoxyqualone include dizziness, nausea, vomiting, and headache. More serious side effects can include respiratory depression, seizures, and dependence.

History

Methoxyqualone was first synthesized in the 1960s as a safer alternative to barbiturates. However, it was later found to have a high potential for abuse and dependence, leading to its withdrawal from many markets.

See also

• Quinazolinone
• GABA_A receptor
• Barbiturate