Methoxyqualone

Methoxyqualone

Structure of Methoxyqualone

Methoxyqualone is a quinazolinone-class sedative and hypnotic drug that is structurally related to methaqualone. It was first synthesized in the 1960s and has been used in some countries as a pharmaceutical for its anxiolytic and muscle relaxant properties. Methoxyqualone is known for its ability to induce sedation, hypnosis, and muscle relaxation.

Chemical Structure and Properties

Methoxyqualone is chemically known as 2-methoxy-3-(2-methylphenyl)-4(3H)-quinazolinone. It is a derivative of methaqualone, with a methoxy group at the 2-position of the quinazolinone ring. This modification alters its pharmacological profile compared to methaqualone.

The chemical structure of methoxyqualone consists of a quinazolinone core, which is a bicyclic structure composed of a benzene ring fused to a pyrimidine ring. The presence of the methoxy group contributes to its unique pharmacokinetic and pharmacodynamic properties.

Pharmacology

Methoxyqualone acts as a central nervous system depressant. It is believed to exert its effects by modulating the activity of gamma-aminobutyric acid (GABA) receptors, similar to other quinazolinone derivatives. This action results in increased inhibitory neurotransmission, leading to sedation and muscle relaxation.

The drug has been used for its anxiolytic effects, helping to reduce anxiety and tension. It also possesses hypnotic properties, making it useful for inducing sleep in patients with insomnia.

Medical Uses

Methoxyqualone has been used in the past for the treatment of anxiety disorders, insomnia, and as a muscle relaxant. However, due to concerns about its potential for abuse and dependence, its use has been limited and it is not widely available in many countries.

Side Effects and Risks

The use of methoxyqualone can lead to several side effects, including drowsiness, dizziness, and impaired coordination. In higher doses, it can cause respiratory depression, which can be life-threatening. Long-term use can lead to tolerance, dependence, and withdrawal symptoms upon cessation.

Legal Status

Methoxyqualone is a controlled substance in many countries due to its potential for abuse and addiction. Its legal status varies, with some countries classifying it as a Schedule I or Schedule II drug, indicating a high potential for abuse and limited medical use.

Related Compounds

Methoxyqualone is related to several other quinazolinone derivatives, including:

• Methaqualone
• Etaqualone
• Mecloqualone

These compounds share similar pharmacological properties and have been used for similar medical purposes.

See Also

• Sedative
• Hypnotic
• Quinazolinone
• Central nervous system depressant

Related Pages

• Methaqualone
• Anxiolytic
• Muscle relaxant