Methylthiouracil

Methylthiouracil is a thiourea derivative used in the treatment of hyperthyroidism. It belongs to the class of antithyroid agents and works by inhibiting the synthesis of thyroid hormones.

Pharmacology

Methylthiouracil is a thioamide, a class of drugs that inhibit the production of thyroid hormones by the thyroid gland. It does this by interfering with the incorporation of iodine into thyroglobulin, which is necessary for the synthesis of thyroxine (T4) and triiodothyronine (T3).

Medical uses

Methylthiouracil is used in the treatment of hyperthyroidism, a condition characterized by an overactive thyroid gland and excessive production of thyroid hormones. It is also used in the preparation for thyroid surgery and for the management of thyroid storm, a severe form of thyrotoxicosis.

Side effects

The most common side effects of methylthiouracil include skin rash, nausea, vomiting, loss of taste, and abdominal pain. In rare cases, it can cause serious side effects such as hepatitis, neutropenia, and agranulocytosis.

Contraindications

Methylthiouracil is contraindicated in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with liver disease due to the risk of hepatotoxicity.

See also

• Propylthiouracil
• Methimazole

Methylthiouracil Resources
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