MicroRNA 138-1

MicroRNA 138-1 (miR-138-1) is a specific type of microRNA that plays a crucial role in various biological processes, including cell differentiation, proliferation, and apoptosis. It is encoded by the MIR138-1 gene and is primarily expressed in the brain and heart.

Function

miR-138-1 is involved in the regulation of gene expression at the post-transcriptional level. It binds to the 3' untranslated region (3' UTR) of target mRNAs, leading to their degradation or translational repression. This microRNA has been implicated in several pathological conditions, including cancer, neurodegenerative diseases, and cardiovascular diseases.

Role in Cancer

miR-138-1 acts as a tumor suppressor in various types of cancer, including breast cancer, lung cancer, and colorectal cancer. It inhibits cancer cell proliferation, migration, and invasion by targeting oncogenes such as FOXC1 and SOX4.

Role in Neurodegenerative Diseases

In neurodegenerative diseases like Alzheimer's disease and Parkinson's disease, miR-138-1 is found to be downregulated. It is believed to play a role in neuronal differentiation and synaptic development, and its dysregulation may contribute to the pathogenesis of these diseases.

Role in Cardiovascular Diseases

miR-138-1 is also involved in the regulation of cardiovascular function. It has been shown to modulate cardiomyocyte proliferation and angiogenesis, and its dysregulation is associated with various cardiovascular diseases, including myocardial infarction and hypertension.

See Also

• MicroRNA
• Gene expression
• Tumor suppressor