MicroRNA 375

MicroRNA 375 (miR-375) is a small non-coding RNA molecule that functions in the regulation of gene expression. It is a member of the microRNA family, which are short RNA molecules that do not code for proteins but instead regulate the expression of other genes.

Function

miR-375 is involved in a variety of biological processes, including cell proliferation, apoptosis, and insulin secretion. It has been found to be highly expressed in the pancreas, where it plays a crucial role in the regulation of insulin secretion.

Role in Disease

Alterations in the expression of miR-375 have been associated with several diseases, including diabetes, cancer, and neurodegenerative diseases. In diabetes, decreased levels of miR-375 have been observed, which may contribute to impaired insulin secretion. In cancer, miR-375 has been found to act as a tumor suppressor in several types of cancer, including breast cancer, lung cancer, and gastric cancer. In neurodegenerative diseases, miR-375 has been found to be involved in the regulation of neuronal cell death.

Research

Research into miR-375 has focused on its potential as a therapeutic target in diseases such as diabetes and cancer. Studies have shown that increasing the expression of miR-375 can improve insulin secretion in diabetic models, and can inhibit tumor growth in cancer models.

See Also

• MicroRNA
• Gene expression
• Insulin
• Diabetes
• Cancer
• Neurodegenerative diseases

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