MicroRNA let-7a-2
MicroRNA let-7a-2 is a specific type of microRNA that plays a crucial role in the regulation of gene expression. It is part of the larger let-7 family of microRNAs, which are known for their involvement in various biological processes, including cell differentiation, proliferation, and apoptosis.
Structure and Function[edit | edit source]
MicroRNA let-7a-2 is a small, non-coding RNA molecule that functions in RNA silencing and post-transcriptional regulation of gene expression. It is encoded by the let-7a-2 gene, which is located on chromosome 11 in humans. The mature let-7a-2 microRNA is produced from a precursor molecule through the action of the Dicer enzyme.
The primary function of let-7a-2 is to regulate gene expression by binding to the 3' untranslated region (3' UTR) of target mRNAs, leading to their degradation or translational repression. This allows let-7a-2 to control the levels of various proteins in the cell, influencing numerous cellular processes.
Role in Disease[edit | edit source]
Alterations in the expression of microRNA let-7a-2 have been associated with several diseases, particularly cancer. For instance, reduced levels of let-7a-2 have been observed in lung cancer, breast cancer, and colorectal cancer, suggesting a potential role as a tumor suppressor. Conversely, overexpression of let-7a-2 has been linked to autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus.
Therapeutic Potential[edit | edit source]
Given its involvement in disease, microRNA let-7a-2 is being explored as a potential therapeutic target. Strategies include the use of microRNA mimics or antagomirs to modulate the levels of let-7a-2 in the cell, with the aim of restoring normal gene expression patterns and cellular function.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD