Midkine

From WikiMD's WELLNESSPEDIA

Midkine (also known as MK, NEGF2, or MDK) is a protein that in humans is encoded by the MDK gene. Midkine is a heparin-binding growth factor that is expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration.

Function[edit]

Midkine is a retinoic acid-responsive, heparin-binding growth factor that is expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinoma cell lines, suggesting that it may play a role in tumor genesis, perhaps through its effects on angiogenesis.

Clinical significance[edit]

Midkine is overexpressed in many cancers, including ovarian cancer, neuroblastoma, and Wilms' tumor. It is also overexpressed in inflammatory diseases such as rheumatoid arthritis and atherosclerosis. Because of its overexpression in these diseases, midkine is a potential target for drug therapy.

See also[edit]

References[edit]


External links[edit]


Stub icon

This WikiMD article can only be edited by registered and verified editors. You can log in or register.

Sponsored Health Resource

W8MD weight loss success

W8MD Weight Loss, Sleep & MedSpa

Looking for physician-supervised weight loss, semaglutide, tirzepatide, or GLP-1 receptor agonist options? W8MD helps eligible patients in New York City, Brooklyn, New Jersey, Connecticut, Pennsylvania, Delaware, and greater Philadelphia with medical weight loss, sleep medicine, and long-term maintenance support.

GLP-1 specials: Affordable GLP-1 injections NYC and Philadelphia starting from $29.99/week and up for semaglutide with insurance accepted for qualifying visits, and $45/week and up for tirzepatide with insurance accepted for qualifying visits. Self-pay options start from $59.99/week and up for semaglutide and $69.99/week and up for tirzepatide.

Book a W8MD appointment · View GLP-1 specials

Paid promotional message. Eligibility, pricing, insurance coverage, medication availability, and results vary. Medical evaluation required.

Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Retrieved from "https://wikimd.org/index.php?title=Midkine&oldid=5298566"