Monosomy
Monosomy is a type of chromosomal abnormality in which there is loss of one chromosome from a normal diploid organism. This can occur in any chromosome, but is most commonly seen in the sex chromosomes. Monosomy can lead to a variety of genetic disorders, depending on the specific chromosome that is missing.
Causes[edit | edit source]
Monosomy can occur due to a variety of reasons. The most common cause is nondisjunction, which is the failure of a pair of chromosomes to separate properly during meiosis. This can result in one gamete receiving two copies of a chromosome and the other receiving none. If a gamete missing a chromosome fertilizes with a normal gamete, the resulting offspring will have monosomy.
Types[edit | edit source]
There are several types of monosomy, including:
- Turner syndrome: This is a condition in which a female is missing one X chromosome. Symptoms can include short stature, infertility, and heart defects.
- Cri du chat syndrome: This is caused by a deletion of the short arm of chromosome 5. Symptoms can include intellectual disability, delayed development, and a distinctive cry that sounds like a cat.
Diagnosis[edit | edit source]
Monosomy can be diagnosed through a variety of methods, including karyotyping, fluorescence in situ hybridization (FISH), and comparative genomic hybridization (CGH).
Treatment[edit | edit source]
There is currently no cure for monosomy. Treatment typically focuses on managing symptoms and improving quality of life. This can include physical therapy, speech therapy, and educational support.
See also[edit | edit source]
Monosomy Resources | ||
---|---|---|
|
|
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Contributors: Prab R. Tumpati, MD