Muscarinic acetylcholine receptor M1

Muscarinic acetylcholine receptor M1 (also known as M1 receptor) is a type of muscarinic receptor, one of the many types of receptors in the human body. It is encoded by the human gene CHRM1.

Function

The M1 receptor is found predominantly in the central nervous system and in peripheral tissues as well. It is predominantly found in the cerebral cortex, hippocampus, and striatum. It is involved in higher cognitive functions such as learning and memory.

The M1 receptors are known to be involved in the regulation of gastric acid secretion, smooth muscle contraction, and thermoregulation. They also play a role in mediating the effects of acetylcholine in the central nervous system.

Structure

The M1 receptor is a G protein-coupled receptor that is coupled to Gq/11 type of G proteins. Activation of the receptor leads to activation of phospholipase C and production of inositol trisphosphate and diacylglycerol, which in turn leads to an increase in intracellular calcium levels.

Clinical significance

Alterations in the function of the M1 receptor have been implicated in several neurological and psychiatric disorders including Alzheimer's disease, schizophrenia, and Parkinson's disease.

File:Muscarinic acetylcholine receptor M1.png

Muscarinic acetylcholine receptor M1

See also

• Muscarinic acetylcholine receptor
• Acetylcholine
• G protein-coupled receptor