Myelokathexis
Myelokathexis | |
---|---|
Synonyms | |
Pronounce | N/A |
Specialty | N/A |
Symptoms | Neutropenia, recurrent infections, warts, hypogammaglobulinemia |
Complications | |
Onset | |
Duration | |
Types | |
Causes | Mutations in the CXCR4 gene |
Risks | |
Diagnosis | Blood test, genetic testing |
Differential diagnosis | |
Prevention | |
Treatment | Granulocyte colony-stimulating factor, immunoglobulin replacement therapy |
Medication | |
Prognosis | |
Frequency | Rare |
Deaths |
Myelokathexis is a rare congenital disorder characterized by a failure of neutrophils, a type of white blood cell, to enter the bloodstream from the bone marrow. This results in severe neutropenia, or a low neutrophil count, leading to increased susceptibility to bacterial infections. The term "myelokathexis" comes from the Greek words "myelo" (marrow) and "kathexis" (retention), reflecting the retention of neutrophils in the bone marrow.
Causes[edit | edit source]
Myelokathexis is caused by mutations in the CXCR4 gene. This gene provides instructions for making a protein that is involved in the movement of cells, including neutrophils. Mutations in the CXCR4 gene disrupt the normal movement of neutrophils, causing them to be retained in the bone marrow.
Symptoms[edit | edit source]
The main symptom of myelokathexis is recurrent bacterial infections, which can be severe and life-threatening. These infections can affect various parts of the body, including the skin, lungs, and urinary tract. Other symptoms may include fever, fatigue, and weight loss.
Diagnosis[edit | edit source]
Myelokathexis is diagnosed based on the clinical symptoms, a complete blood count showing neutropenia, and a bone marrow examination showing an increased number of mature neutrophils. Genetic testing can confirm the diagnosis by identifying a mutation in the CXCR4 gene.
Treatment[edit | edit source]
Treatment for myelokathexis is aimed at managing the symptoms and preventing infections. This may include antibiotics to treat existing infections and prophylactic antibiotics to prevent new infections. In severe cases, a bone marrow transplant may be considered.
See also[edit | edit source]
References[edit | edit source]
Transform your life with W8MD's budget GLP1 injections from $125 and up biweekly
W8MD offers a medical weight loss program NYC and a clinic to lose weight in Philadelphia. Our W8MD's physician supervised medical weight loss centers in NYC provides expert medical guidance, and offers telemedicine options for convenience.
Why choose W8MD?
- Comprehensive care with FDA-approved weight loss medications including:
- loss injections in NYC both generic and brand names:
- weight loss medications including Phentermine, Qsymia, Contrave, Diethylpropion etc.
- Accept most insurances for visits or discounted self pay cost.
- Generic weight loss injections starting from just $125.00 for the starting dose
- In person weight loss NYC and telemedicine medical weight loss options in New York city available
Book Your Appointment
Start your NYC weight loss journey today at our NYC medical weight loss, and Philadelphia and visit Philadelphia medical weight loss Call (718)946-5500 for NY and 215 676 2334 for PA
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's NYC physician weight loss.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available. Call 718 946 5500.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD