N-Acetylneuraminic acid

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N-Acetylneuraminic acid

0N-Acetylneuraminic acid (also known as Neu5Ac) is a derivative of the monosaccharide neuraminic acid. It is a significant component of glycoconjugates, such as glycoproteins and glycolipids, which contribute to cellular functions like cell-cell interaction, molecular recognition, and immune response.

Structure and Properties[edit | edit source]

N-Acetylneuraminic acid is a nine-carbon monosaccharide. It is composed of a pyranose ring with an acetyl group attached to the fifth carbon and a carboxyl group at the second carbon. The molecule also contains a hydroxyl group at the third and fourth carbons and a N-acetyl group at the fifth carbon.

Biological Role[edit | edit source]

N-Acetylneuraminic acid plays a crucial role in biological systems. It is a major component of the glycocalyx, a glycoprotein and glycolipid covering that surrounds the cell membranes of some cells. It is also involved in various biological processes such as cell-cell adhesion, immune response, and pathogen recognition.

In humans, N-Acetylneuraminic acid is the predominant sialic acid found in the brain, milk, and other tissues. It is also a key component of gangliosides, which are complex glycosphingolipids present in the plasma membrane of nerve cells.

Synthesis and Metabolism[edit | edit source]

N-Acetylneuraminic acid is synthesized from glucose and glutamine in a pathway that involves several enzymes, including UDP-N-acetylglucosamine 2-epimerase and sialic acid synthase. It can be metabolized by sialidase enzymes, which cleave the glycosidic linkages of sialic acids.

Clinical Significance[edit | edit source]

Alterations in the metabolism of N-Acetylneuraminic acid have been associated with various diseases, including cancer, influenza, and neurodegenerative diseases. For instance, many cancer cells have an increased expression of sialic acids on their surface, which can contribute to their ability to evade the immune system.


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Contributors: Prab R. Tumpati, MD